State dependent coupling of hippocampal oscillations

EBRI, in collaboration with Prof. Francesco Battaglia of the Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Netherlands, has developed a new analytical method that allows to study oscillations occurring simultaneously at different frequencies in certain brain areas. Oscillations, generated by large neuronal ensembles, play a key role in high cognitive functions as, through the synchronization of various neural activities present in different brain areas, they promote the precise temporal coordination of neural processes underlying memory, perception and behavior.
Traditional approaches for the study of brain oscillations are typically based on analyzing spectral features of individual oscillations (univariate methods) or the power and phase relationship between two oscillations (bivariate methods). The present study presents a different, multivariate, approach to simultaneously analyze interactions between multiple oscillations and applied it to Local Field Potentials recorded in vivo from the hippocampus of mice chronically implanted with tetrodes and silicon probes and free to move in a platform. This innovative method provides a comprehensive and convincing approach to characterize oscillatory network states, opening new avenues for studying the complex interactions that characterize neural circuit dynamics.
This study constituted the PhD thesis project of Brijesh Modi, currently Post Doc at the laboratory "Sleep and Cognitive Development, Norwegian Center for Molecular Medicine, University of Oslo, Norway".

Modi B, Guardamagna M, Stella F, Griguoli M, Cherubini E, Battaglia FP. State dependent coupling of hippocampal oscillations. Elife. 2023 Jul 18;12:e80263. doi: 10.7554/eLife.80263.