New study clarifies the effects of stress on memory
A recent work published on “Proceedings of the National Academy of Sciences” has investigated how chronic stress alters the adaptive responses of the brain to familiar and novel experiences. This study elucidated the molecular substrates underlying adaptive or maladaptive plasticity. Specifically, it has been demonstrated how different environmental stimuli impact the function of critical neuronal circuits through epigenetic mechanisms that regulate glutamatergic transmission, known to play a fundamental role in learning and memory.
The work conducted by Dr Carla Nasca and coordinated by Prof McEwen from the Rockfeller University of New York, is the result of a collaboration between different laboratories, including the EBRI Rita Levi-Montalcini Institute and Sapienza University of Rome, which have recently signed a collaboration agreement.
Nasca C, Zelli D, Bigio B, Piccinin S, Scaccianoce S, Nisticò R, McEwen BS. Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity. Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14960-5. doi: 10.1073/pnas.1516016112