The research at EBRI is based on a set of laboratories, each of them headed by a group leader. In most cases the group leader are young Italian and foreign scientists who were given the chance and the funding resources to start their independent research activity within a modern institute.

The group leader selection was based on the excellence of the scientific career and the publication record. Every laboratory work as an independent research unit, while exploiting all the common infrastructures and facilities and taking part to common projects and institute activities, involving both EBRI laboratories and other research centres.