Education and Experiences

RESEARCH/TEACHING EXPERIENCE

2008 - : Lecturer in Pharmacology and Principal Investigator, Royal Veterinary College and Consortium for Mitochondrial Research (CfMR), University College London

2005 - 2008: PostDoctoral Research Fellow, Department of Physiology and Centre for Clinical Pharmacology and Therapeutics, UCL

2005 - 2007: Marie Curie Research Fellow

2005: Accademia dei Lincei/Royal Society Research Fellow

2005: EMBO Short Term Fellow

TRAINING AND TITLES

2010-: Local Ambassador of the Biochemical Society

2005-: Member of the Royal Pharmaceutical Society

2002-2005: PhD student in "Cellular and Molecular Pharmacology" University of Ferrara, Italy Supervisor Prof. Rosario Rizzuto, date of award 23^rd February 2005

2000: Project Student in the laboratory of Prof. EA Schoen, Departments of Neurology and Genetics, Columbia University College of Physicians and Surgeons, New York, U.S.A.

1996-2001: Degree in Pharmacy, University of Ferrara, Italy, date of award 16^th July 2001.

1991-1996: Humanities, Verona, Italy

Publications

Gastaldello A, Gami P, Callaghan H and Campanella M*. 2010. Ca2+ dependent autophagy is enhanced by the Pharmacological Agent PK11195. Autophagy July 6;6(5). 2010. *Corresponding/Senior author.

Hall A, Campanella M, Loesch A, Duchen M, and Unwin R. 2010 “Albumin endocytosis in OK cells exposed to rotenone: an ´OKay´ model for the effects of mitochondrial dysfunction on the proximal tubule?" Nephron Physiol. 12;115(2) 2010.

Pavlov E, Aschar-Sobbi R, Campanella M, Turner RJ, Gomez-Garcia MR, Abramov AY. Inorganic polyphosphate and energy metabolism in mammalian cells. 2010. Journal of Biological Chemistry 2010 Mar 26;285(13):9420-8.

Rossi CA, Pozzobon M, Ditadi A, Archacka K, Gastaldello A, Sanna M, Franzin C, Malerba A, Milan G, Cananzi M, Schiaffino S, Campanella M*, Vettor R, De Coppi P. 2010. Clonal characterization of muscle satellite cells: proliferation, metabolism and differentiation define an intrinsic heterogeneity. Plos One 1;5(1):e8523. *Corresponding/Senior author

Ferrari D#, Pinton P#, Campanella M#*, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R*. 2009. Functional and structural alterations in the Endoplasmic Reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. Biochem Biophys Res Commun. 2009 Nov 24. #Equally contributed;*Corresponding author.

Campanella M, Parker N, Tan CH, Hall AM and Duchen MR. 2009. IF1: setting the pace of the F1Fo-ATP synthase. Trends in Biochemical Sciences (TiBs). Jul;34(7):343-50.

Campanella M*, Seraphin A, Abeti R, Casswell E, Echave P and Duchen MR. 2009. IF1, the F1Fo-ATPsynthase endogenous regulator, defines mitochondrial volume fraction in HeLa cells by regulating basal autophagy. Biochimica and Biophysica Acta (BBA);1787(5):393-401. *Corresponding author.

Campanella M*, Szabadkai G and Rizzuto R. Modulation of Intracellular Ca2+ Signalling in HeLa Cells by the Apoptotic Cell Death Enhancer PK11195. 2008. Biochemical Pharmacology 1;76(11):1628-36. *Corresponding author.

Campanella M, Farah Z, Casswell E, Chong S , Wieckowski MR , Abramov AY, Tinker A and Duchen MR. 2008. Regulation of Mitochondrial Structure and Function by the F(1)F(o)-ATPase Inhibitor Protein, IF(1). Cell Metabolism Jul;8(1):13-25.

McKenzie M, Liolitsa D, Akinshina N, Campanella M, Sisodiya S, Hargreaves I, Nirmalananthan N, Sweeney MG, Abou-Sleiman PM, Wood NW, Hanna MG, Duchen MR. 2007. Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption. Journal of Biological Chemistry, 21;282(51):36845-52.

Hoyer-Hansen M, Bastholm L,  Szyniarowski P, Campanella M,  Szabadkai G,  Farkas T, Bianchi K, Fehrenbacher N,  Elling F,  Rizzuto R, Mathiasen IS, Jaattela M. 2007.  Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-ß and Bcl-2. Moll. Cell. 25(2):193-205).

Research Projects

Mitochondrial dysfunction appears as the most acknowledged parallel among neurodegenerative disorders such as Alzheimer´s, Parkinson´s and Huntington´s. Many lines of evidence have thus indicated that mitochondria play a central role in the pathologies of the central nervous system associated to progressive and irreversible degeneration of tissues -especially in those ageing related.

Mitochondria define the energetic balance of the cell (i), serve as a conduit for commitment to life and death (ii), fine tune Ca²⁺ signaling (iii) and contribute to the oxidative stress (iv); it is therefore clear that perturbation of their homeostasis can be detrimental for the highly challenged cells composing the brain.

In the recent years, most of the research of Dr Campanella has been dedicated to investigate two fundamental concepts associated with the biology of mitochondria and lying at the basis of the whole cellular health: ENERGY and QUALITY. PATHWAYS and MOLECULES which may concomitantly impinge on both these aspects have been therefore objectives of my attention aiming to provide information of vital aspects of normal and abnormal cell function.

Therefore his research efforts at the EBRI will be dedicated to address how bio-energy and its associated quality control impinge on the onset and progression of neurodegeneration in order to identify molecular targets for pharmacological intervention.

In this respect two principal topics have been identified on which found the future research activity:

1. The glycolytic driven metabolism and the reversion of the mitochondrial F₁Fo-ATPsynthase in cell pathology.

2. The functional role of the mitochondrial Translocator Protein (mTSPO) in the upset of metabolism and self-conservation mechanisms guarding the cell integrity.

The research work of the unit won’t be dedicated just to the understanding of the neurodegneration but also to the most severe form of cancer associated with the brain such as: a) neuroblastoma and b) glioblastoma. This will permit to insight on the features of neuro-oncology and to benefit of the community of high profile scientists and clinicians active in the field within the national and local panorama.

In this respect, major are the hints so far obtained to link mitochondrial and cell metabolism to the onset and unfolding of the severe and difficult to treat pathologies.

Awards

BBSRC New Investigator Award (2011)

Selected Young Scientist for the 57^Th MEETING OF NOBEL LAUREATES in MEDICINE (July 2007);

MARIE CURIE Intra European Fellowship (EIF) for LIFE SCIENCES (July 2005);

Scientific Collaborations

Group Members

Ramona Lupi (PostDoctoral Research Fellow)

Cetty Lena (Research Assistant)

Cinzia Agostini (Personal Assistant and Lab Manager)