European Brain Research Institute - Rita Levi-Montalcini

Capsoni S, Tiveron C, Vignone D, Amato G, Cattaneo A. Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proc Natl Acad Sci U S A. 2010 Jun 21. [Epub ahead of print]

Amadoro G, Corsetti V, Stringaro A, Colone M, D´Aguanno S, Meli G, Ciotti M, Sancesario G, Cattaneo A, Bussani R, Mercanti D, Calissano P. A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration. J Alzheimers Dis. 2010 Jun 21. [Epub ahead of print]

Capsoni S, Tiveron C, Amato G, Vignone D, Cattaneo A. Peripheral neutralization of nerve growth factor induces immunosympathectomy and central neurodegeneration in transgenic mice. J Alzheimers Dis. 2010;20(2):527-46

Paoletti F, Ainger K, Donati I, Scardigli R, Vetere A, Cattaneo A, Campa C. Novel fluorescent cycloheximide derivatives for the imaging of protein synthesis. Biochem Biophys Res Commun. 2010 May 28;396(2):258-64. Epub 2010 Apr 23

Marie H and Nolan M Virus-based technologies for investigating function and pathology of the nervous system. Front. Cell. Neurosci. 2010, 3(16): 1-2

Batassa EM, Costanzi M, Saraulli D, Scardigli R, Barbato C, Cogoni C, Cestari V. RISC activity in hippocampus is essential for contextual memory. Neurosci Lett. 2010 Mar 8;471(3):185-8. Epub 2010 Jan 28

Lagostena L, Rosato-Siri M, D´Onofrio M, Brandi R, Arisi I, Capsoni S, Franzot J, Cattaneo A, Cherubini E. In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction. J Neurosci. 2010 Jan 20;30(3):885-93

Marchetti C., Tafi E., Middei S., Rubinacci M., Restivo L., Ammassari-Teule M., and Marie H. Synaptic adaptations of CA1 pyramidal neurons induced by a highly effective combinational antidepressant therapy. Biological Psychiatry 2010, 67(2):146-54

Covaceuszach S, Capsoni S, Marinelli S, Pavone F, Ceci M, Ugolini G, Vignone D, Amato G, Paoletti F, Lamba D, Cattaneo A. In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V. Biochem Biophys Res Commun. 2010 Jan 1;391(1):824-9. Epub 2009 Nov 27.

Amadoro G, Corsetti V, Ciotti MT, Florenzano F, Capsoni S, Amato G, Calissano P Endogenously Abeta causes cell death via early tau hyperphosphorylation. Neurobiol Aging 2009.

D´Onofrio M, Arisi I, Brandi R, Di Mambro A, Felsani A, Capsoni S and Cattaneo A Early inflammation and immune response mRNAs in the brain of AD11 anti-NGF mice. Neurobiol Aging 2009 Jul 13. [Epub ahead of print]

Barbato C, Arisi I, Frizzo ME, Brandi R, Da Sacco L and Masotti A. Computational Challenges in miRNA Target Predictions: To Be or Not to Be a True Target? J Biomed Biotechnol 2009:803069

Paoletti F, Covaceuszach S, Konarev PV, Gonfloni S, Malerba F, Schwarz E, Svergun DI, Cattaneo A, Lamba D (2009) Intrinsic structural disorder of mouse proNGF. Proteins 75, 990-1009

Origlia N, Capsoni S, Cattaneo A, Fang F, Arancio O, Yan SD, Domenici L,  Aß-Dependent Inhibition of LTP in Different Intracortical Circuits of the Visual Cortex: The Role of RAGE. J Alzheimers Dis. 2009 May;17(1):59-68

Meli G, Visintin M, Cannistraci I, Cattaneo A (2009) Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer´s amyloid-beta oligomers. J Mol Biol 387, 584-606

Covaceuszach S, Capsoni S, Ugolini G, Spirito F, Vignone D, Cattaneo A (2009) Development of a non invasive NGF-based therapy for Alzheimer´s disease. Curr Alzheimer Res 6, 158-170

Huang Y. H., Lin Y., Mu P., Lee B., Brown T., Wayman G., Marie H., Liu W., Yan Z., Sorg B.A., Schluter O., Zukin R.S., Dong Y. In vivo Cocaine Experience Generates Silent Synapses. Neuron 2009, 63:40-47

Peng Y. , He S., Marie H., Zeng S., Ma J., Tan Z., Lee S.Y., Malenka R.C., Yu X. Coordinated changes in dendritic arborization and synaptic strength during neural circuit development. Neuron 2009 Jan 15;61(1):71-84

Capsoni S, Covaceuszach S, Ugolini G, Spirito F, Vignone D, Stefanini B, Amato G, Cattaneo A (2009) Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice. J Alzheimers Dis 16, 371-388

Restivo L., Tafi E., Ammassari-Teule M., Marie H. Viral-mediated expression of a constitutively active form of CREB in hippocampal neurons increases memory. Hippocampus 2009, 19:228-234

Marinelli S, Pacioni S, Cannich A, Marsicano G, Bacci A. (2009) Self-modulation of neocortical glutamatergic neurons by endocannabinoids. Nature Neurosci 12:1488-90

Zacchi P, Dreosti E, Visintin M, Moretto-Zita M, Marchionni I, Cannistraci I, Kasap Z, Betz H, Cattaneo A, Cherubini E (2008) Gephyrin selective intrabodies as a new strategy for studying inhibitory receptor clustering. J Mol Neurosci 34, 141-148

Visintin M, Melchionna T, Cannistraci I, Cattaneo A (2008) In vivo selection of intrabodies specifically targeting protein-protein interactions: a general platform for an "undruggable" class of disease targets. J Biotechnol 135, 1-15

Matrone Ca, Di Luzio Aa, Meli Gb, D’Aguanno Sc,d, Severini Ca, Ciotti MTa, Cattaneo Ab,e and Calissano P (2008) 81-96. Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells (2007) J.Alzheimer.s Disease 13, 81-96

Terzibasi E, Valenzano DR, Benedetti M, Roncaglia P, Cattaneo A, Domenici L, Cellerino A (2008) Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri. PLoS One 3, e3866

Origlia N, Righi M, Capsoni S, Cattaneo A, Fang F, Stern DM, Chen JX, Schmidt AM, Arancio O, Yan SD, Domenici L (2008) Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction. J Neurosci 28, 3521-3530

Matrone C, Di Luzio A, Meli G, D´Aguanno S, Severini C, Ciotti MT, Cattaneo A, Calissano P (2008) Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells. J Alzheimers Dis 13, 81-96

Covaceuszach S, Cassetta A, Konarev PV, Gonfloni S, Rudolph R, Svergun DI, Lamba D, Cattaneo A (2008) Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody. J Mol Biol 381, 881-896

Corsetti V, Amadoro G, Gentile A, Capsoni S, Ciotti MT, Cencioni MT, Atlante A, Canu N, Rohn TT, Cattaneo A, Calissano P (2008) Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer´s disease models. Mol Cell Neurosci 38, 381-392

Cattaneo A, Capsoni S, Paoletti F (2008) Towards non invasive Nerve Growth Factor therapies for Alzheimer´s disease. Journal of Alzheimer´s disease 15, 255-283

Farioli-Vecchioli S, Saraulli D, Costanzi M,  Pacioni S, Cinà I, Aceti M, Micheli L, Bacci A, Cestari V, Tirone F. The timing of differentiation of adult hippocampal neurons is crucial for spatial memory. (2008) PLoS Biol. 6:e246

Marinelli S, Pacioni S, Bisogno T, Di Marzo V, Prince DA, Huguenard JR, Bacci A. The endocannabinoid 2-AG is responsible for the slow self inhibition in neocortical interneurons. J Neurosci (2008) 28:13532-13541

Ugolini G, Marinelli S, Covaceuszach S, Cattaneo A, Pavone F (2007) The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain. Proc Natl Acad Sci U S A 104, 2985-2990

Melchionna T, Cattaneo A (2007) A protein silencing switch by ligand-induced proteasome-targeting intrabodies. J Mol Biol 374, 641-654

Cavalli A, Bolognesi ML, Capsoni S, Andrisano V, Bartolini M, Margotti E, Cattaneo A, Recanatini M, Melchiorre C (2007) A small molecule targeting the multifactorial nature of Alzheimer´s disease. Angew Chem Int Ed Engl 46, 3689-3692

Bolognesi ML, Banzi R, Bartolini M, Cavalli A, Tarozzi A, Andrisano V, Minarini A, Rosini M, Tumiatti V, Bergamini C, Fato R, Lenaz G, Hrelia P, Cattaneo A, Recanatini M, Melchiorre C (2007) Novel Class of Quinone-Bearing Polyamines as Multi-Target-Di rected Ligands To Combat Alzheimer´s Disease. J Med Chem

Berardi N, Braschi C, Capsoni S, Cattaneo A, Maffei L (2007) Environmental enrichment delays the onset of memory deficits and reduces neuropathological hallmarks in a mouse model of Alzheimer-like neurodegeneration. J Alzheimers Dis 11, 359-370

Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 16, 296-300

Valenzano DR, Terzibasi E, Cattaneo A, Domenici L, Cellerino A (2006) Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri. Aging Cell 5, 275-278

Sola E, Capsoni S, Rosato-Siri M, Cattaneo A, Cherubini E (2006) Failure of nicotine-dependent enhancement of synaptic efficacy at Schaffer-collateral CA1 synapses of AD11 anti-nerve growth factor transgenic mice. Eur J Neurosci 24, 1252-1264

Rosato-Siri M, Cattaneo A, Cherubini E (2006) Nicotine-induced enhancement of synaptic plasticity at CA3-CA1 synapses requires GABAergic interneurons in adult anti-NGF mice. J Physiol 576, 361-377

Rende M, Pistilli A, Stabile AM, Terenzi A, Cattaneo A, Ugolini G, Sanna P (2006) Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. Anticancer Drugs 17, 929-941

Paoletti F, Konarev PV, Covaceuszach S, Schwarz E, Cattaneo A, Lamba D, Svergun DI (2006) Structural and functional properties of mouse proNGF. Biochem Soc Trans 34, 605-606

Dong Y., Green T., Saal D., Marie H., Neve R., Nestler E.J., Malenka R.C. CREB modulates excitability of nucleus accumbens neurons. Nat Neurosci. 2006 Apr;9(4):475-7

Origlia N, Capsoni S, Domenici L, Cattaneo A (2006) Time window in cholinomimetic ability to rescue long-term potentiation in neurodegenerating anti-nerve growth factor mice. J Alzheimers Dis 9, 59-68

Capsoni S, Cattaneo A (2006) On the molecular basis linking Nerve Growth Factor (NGF) to Alzheimer´s disease. Cell Mol Neurobiol 26, 619-633

Berrera M, Cattaneo A, Carloni P (2006) Molecular simulation of the binding of nerve growth factor peptide mimics to the receptor tyrosine kinase A. Biophys J 91, 2063-2071

S.Cavallaro and P.Calissano (2006) A genomic approach to investigate neuronal apoptosis. Current Alzheimer research 3, 4-23

Arisi I, Cattaneo A, Rosato V (2006) Parameter estimate of signal transduction pathways. BMC Neurosci 7 Suppl 1, S6

Bacci A., Huguenard JR. (2006) Enhancement of spike timing precision by autaptic transmission in neocortical inhibitory interneurons. Neuron 49:119-30

Vascotto F, Visintin M, Cattaneo A, Burrone OR (2005) Design and selection of an intrabody library produced de-novo for the non-structural protein NSP5 of rotavirus. J Immunol Methods 301, 31-40

Pattabiraman PP, Tropea D, Chiaruttini C, Tongiorgi E, Cattaneo A, Domenici L (2005) Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. Mol Cell Neurosci 28, 556-570

Mladinic M, Wintzer M, Del Bel E, Casseler C, Lazarevic D, Crovella S, Gustincich S, Cattaneo A, Nicholls J (2005) Differential expression of genes at stages when regeneration can and cannot occur after injury to immature mammalian spinal cord. Cell Mol Neurobiol 25, 407-426

Genade T, Benedetti M, Terzibasi E, Roncaglia P, Valenzano DR, Cattaneo A, Cellerino A (2005) Annual fishes of the genus Nothobranchius as a model system for aging research. Aging Cell 4, 223-233

Fasulo L, Ugolini G, Cattaneo A (2005) Apoptotic effect of caspase-3 cleaved tau in hippocampal neurons and its potentiation by tau FTDP-mutation N279K. J Alzheimers Dis 7, 3-13

De Rosa R, Garcia AA, Braschi C, Capsoni S, Maffei L, Berardi N, Cattaneo A (2005) Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci U S A 102, 3811-3816

Barbato,C. Canu,N. Zambrano,N. Serafino,A. Minopoli G. Ciotti,M.T. Amadoro,G. Russo,T. and Calissano P. (2005) Interaction of tau with Fe65 links tau to APP. Neurobiology of Disease, 18, 399-408

Covaceuszach S, Cattaneo A, Lamba D (2005) Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight. Proteins 58, 717-727

Nolan T, Braccini L, Azzalin G, De Toni A, Macino G, Cogoni C. (2005) The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa. Nucl Acids Research 33:1564-73