Antonino Cattaneo has worked as a PhD student at the Scuola Normale Superiore (Pisa) with Lamberto Maffei and as a postdoc and staff scientist with Rita Levi-Montalcini (Nobel Prize Laureate for discovery of NGF) at the CNR Institute of Neurobiology in Rome, and with Cesar Milstein (Nobel Prize laureate for discovery of monoclonal antibodies) at the MRC Laboratory of Molecular Biology (Cambridge, UK).
From 1991 to 2008, he was Full Professor of Biophysics at the International School for Advanced Studies (SISSA) in Trieste (Italy), where he was Head of the Biophysics Department from 1991 to 1995 and the Deputy Director of SISSA from 1996 to 2001. From 2008 to present he is Professor of Neurobiology at the Scuola Normale Superiore (Pisa), where he is the Director of the Biology Lab BioSnS.
Antonino Cattaneo is author of numerous publications in peer-reviewed international journals and is recipient of several awards including Domenico Marotta Prize, Italian Academy of Sciences XL, the W. Jansenius Medal, Slovak Academy of Sciences and the “G. Tartufari” International Prize for Biology, Accademia Nazionale dei Lincei.
He is a member of EMBO (European Mo¬lecular Biology Organization) and member of the Italian Academy of Sciences XL.
He is former member of the Council of Scientists of Human Frontier Science Program Organization (HFSPO), for which he has also served for four years as the Chairman of the Grants Review Committee. He has been Visiting Fellow of Trinity College in Cambridge (UK). He is a Team Leader of the European Neuroscience Institute Young Investigator Network.
Memberships and Awards:
Shortlist of representative papers (22 out of over 205):
Biocca S, Neuberger MS, Cattaneo A (1990) Expression and targeting of intracellular antibodies in mammalian cells. EMBO J 9:101-108.
Piccioli P, Ruberti F, Biocca S, Di Luzio A, Werge TM, Bradbury A, Cattaneo A (1991) Neuroantibodies: molecular cloning of a monoclonal antibody against substance P for expression in the central nervous system. Proc Natl Acad Sci U S A 88:5611-5615.
Tavladoraki P, Benvenuto E, Trinca S, De Martinis D, Cattaneo A, Galeffi P (1993) Transgenic expressing a functional single-chain Fv antibody are specifically protected from virus attack. Nature 366:469-472.
Bradbury A, Persic L, Werge T, Cattaneo A (1993) Use of living columns to select specific phage antibodies. Nature Biotechnology 11:1565-1569.
Berardi N, Cellerino A, Domenici L, Fagiolini M, Pizzorusso T, Cattaneo A, Maffei L (1994) Monoclonal antibodies to nerve growth factor affect the postnatal development of the visual system. Proc Natl Acad Sci U S A 91:684-688.
Biocca S, Pierandrei-Amaldi P, Campioni N and Cattaneo A (1994) Intracellular immunization with cytosolic recombinant antibodies. Nature Biotechnology 12:396-399.
Piccioli P, Di Luzio A, Amann R, Schuligoi R, Surani MA, Donnerer J, Cattaneo A (1995) Neuroantibodies: ectopic expression of a recombinant anti-substance P antibody in the central nervous system of transgenic mice. Neuron 15:373-384.
Biocca S, Ruberti F, Tafani M, Pierandrei-Amaldi P and Cattaneo A (1995) Redox state of single chain Fv fragments targeted to the endoplasmic reticulum, cytosol and mitochondria. Nature Biotechnology 13:1110-1115.
Tongiorgi E, Righi M, Cattaneo A (1997) Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons. J Neurosci 17:9492-9505.
Righi M, Tongiorgi E and Cattaneo A (2000) Brain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 kinase-dependent pathway. J Neurosci 20:3165-3174.
Visintin M, Tse E, Axelson H, Rabbitts TH, Cattaneo A (1999) Selection of antibodies for intracellular function using a two-hybrid in vivo system. Proc Natl Acad Sci U S A 96:11723-11728.
Pesavento E, Margotti E, Righi M, Cattaneo A, Domenici L (2000) Blocking the NGF- TrkA interaction rescues the developmental loss of LTP in the rat visual cortex: role of the cholinergic system. Neuron 25:165-175.
Capsoni S, Ugolini G, Comparini A, Ruberti F, Berardi N, Cattaneo A (2000) Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc Natl Acad Sci U S A 97:6826-6831.
Capsoni S, Giannotta S, Cattaneo A (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc Natl Acad Sci U S A 99:12432-12437.
De Rosa R, Garcia AA, Braschi C, Capsoni S, Maffei L, Berardi N, Cattaneo A (2005) Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci U S A 102:3811-3816.
Ugolini G, Marinelli S, Covaceuszach S, Cattaneo A, Pavone F (2007) The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain. Proc.Natl Acad Sci USA 104: 2985-2990.
Capsoni, S., Tiveron, C., Amato, G., Vignone, D., Cattaneo, A. (2010) Dissecting the involvement of Tropomyosin kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proc Natl Acad Sci USA 107: 12299-12304.
Tiveron C et al (2013) proNGF/NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice. Cell Death and Differ., 20(8):1017-30. doi: 10.1038/cdd.2013.22
Meli G, Lecci A, Manca A, Krako N, Albertini V, Benussi L, Ghidoni R, Cattaneo A. (2014) Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum. Nature Commun. 2014 May 27;5:3867. doi: 10.1038/ncomms4867. Highlighted in Alzforum.org.
Capsoni S, Malerba F, Carucci N, Rizzi C, Criscuolo C, Origlia N, Calvello MA, Viegi A, Meli G and Cattaneo A (2016) The chemokine CXCL12 mediates the anti- amyloidogenic actions of painless human Nerve Growth Factor. BRAIN, 140 (1): 201-217. doi:https://doi.org/10.1093/brain/aww271. Editorial highlight.
Chirichella M, Lisi S, Fantini M, Goracci M, Calvello M, Brandi R, Arisi I, D'Onofrio M, Di Primio C, Cattaneo A. (2017) Post-translational selective intracellular silencing of acetylated proteins with de novo selected intrabodies. Nat Methods. 2017 Mar;14(3):279-282. doi: 10.1038/nmeth.4144. Highlighted and commentd in Biocentury.
Gobbo F, Marchetti L, Jacob A, Pinto B, Binini N, Pecoraro Bisogni F, Alia C, Luin S, Caleo M, Fellin T, Cancedda L and Cattaneo A (2017) Activity-dependent expression of Channelrhodopsin at neuronal synapses. Nature Comm. 8, 1629. DOI: 10.1038/s41467- 017-01699-7. Editorial highlight in Nat Comm.