Giuseppe Nisticò

Farmacology Of Synaptic Plasticity



Biographical sketch:

Giuseppe Nisticò, MD, is Full Professor of Pharmacology since 1980.

Qualified in Medicine in 1965 (110/110 with honours) and specialized in Neuropsychiatry (70/70 with honours) in 1968. He was Director of the Institute of Pharmacology, Faculty of Medicine, University of Messina (1976-1983) and then Director of the Institute of Pharmacology, Faculty of Medicine, University of Catanzaro.

From 1990 to 2011 he was Full Professor of Pharmacology, University of Rome, Tor Vergata.

From 1995 to 1998 he was President of the Calabria Region and from 1999 to 2004 was Member of the European Parliament and President of a Committee of the Italian Government for a network of excellence in Biomedicine and Biotechnology.

From 2006 to 2011 he was Director of the Pharmaceutical Biotechnologies Center and of the European School for the Assessment of New Medicines (University of Rome Tor Vergata).

In addition, from 2008 to 2011 he  was President of the Scientific Committee for the New Degree Course in Pharmacy (in English).

From 2011 till now he is responsible for the International Relations of the same Degree Course in Pharmacy.

From 2010 to 2011 he  was Commissioner of the European Brain Research Institute (EBRI) Fondazione “Rita Levi-Montalcini”. Since 2011 he is General Director of EBRI.

Member of the Committee for Human Medicinal Products of the European Medicines Agency (EMA) from 2004 to 2010 and from 2007 he is member of the EMA Management Board.

Author of approx 300 publications in international journals of Pharmacology and Neuroscience and in addition he is author or editor of more than 25 volumes published by international Publishing Companies.

His main scientific interests: role of neurotransmitters in sleep/arousal mechanisms and pharmacological modulation of synaptic plasticity.

Marco Feligioni
Sonia Piccinin
Dalila Mango
Lab Technicians
Caterina Ferraina
Gulielmo Barberini


Selected Publications

  1. Marley E & Niasticò G (1972) _ Effects of catecholamines, and adenosine derivatives given into the brain of fowls. Brit. J. Pharmac. 46, 619-636.

  2. Marley E & Nisticò G (1975) – Tryptamines and some other substances affecting waking and sleep in fowls. Br. J. Pharmac. 53,193-205.

  3. Marley E & Nisticò G (1975) – Central effects of clonidine [2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride] in fowls. Br. J. Pharmac. 55,459-473.

  4. Carruba M, Nisticò G & Gargiulo G (1978) – Effects of central nervous system-acting drugs after selective destruction by neurotoxins of 5-hydroxytryptamine fibers in the brain. Ann. N. Y. Acad. Sci. 305,242-258.

  5. Gargiulo G & Nisticò G (1978) – Time course of 5,6-dihydroxytryptamine neurotoxic effects on fowl diencephalon and upper brain stem monoaminergic pathways. J. Anatomy, 126,261-274.

  6. Racagni G, Apud JA, Locatelli V, Cocchi D, Nisticò G, Di Giorgio RM & Muller EE (1979)- GABA of of CNS origin in the rat anterior pituitary inhibits prolactin secretion. Nature 281,575-578.

  7. De Sarro GB, Ascioti C, Froio F, Libri V & Nisticò G (1987) – Evidence that locus coeruleus is the site where clonide and drugs acting at alfa-1 and alfa-2-adrenoceptors affect sleep and arousal mechanisms. Br. J. Pharmac. 90, 675-685.

  8. De Sarro GB, Meldrum BS & Nisticò G (1988) – Anticonvulsant effects of some calcium entry blockers in DBA/2 mice. Br. J. Pharmac. 93,247-256.

  9. Bagetta G, De Sarro GB, Priolo E & Nisticò G (1988) – Ventral segmenta area, site through which dopamine D-2 receptors agonists evoke behavioural and electrocortical sleep in rats. Br. J. Pharmac. 95,860-866.

  10. De Sarro GB, Bagetta G, Ascioti C, Libri V & Nisticò G (1988) – Microinfusion of clonidine and yohimbine into locus coeruleus alters EEG power ectrum effects of aging and reversal by phosphatidylserine. Br. J. Pharmac. 95,1278-1286.

  11. De Sarro GB, Bagetta G, Ascioti C, Libri V & Nisticò G (1989) – Effects of pertussis toxin on the beahvioural and ECoG spectrum changes induced by cloni dine and yohimbine after their microinfusion into the locus coeruleus. Br. J. Pharmac. 96,59-64.

  12. Mollace V, Masuda Y, Pelaggi T & Nisticò G (1990) – The effects of phosphatidylserine on the decreased cardiovascular response to clonidine microinfused into the nucleus tractus solitarii of old rats. Br. J. Pharmac. 100,547-551.

  13. Bagetta G, De Sarro GB, Sakurada R, Rispoli V & Nisticò G (1990) – Different profile of electrocortical power spectrum changes after microinfusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats. Br. J. Pharmac. 101,655-661.

  14. Nisticò G & De Sarro GB (1991) – Is interleukin 2 a neuromodulator in the brain? Trends in Neurosci. 14, 146-150.

  15. Mollace V, De Francesco EA, Fersini G & Nisticò G (1991) – Age-dependent changes in cardiovascular responses induced by muscimol infused into the nucleus tractus solitarii and nucleus parabrachialis medialis in rats. Br. J. Pharmac. 103, 1802-1806.

  16. Nisticò G, De Sarro GB, Bagetta G & Mollace V (1992) – Altered sensitivity of α2-adrenoreceptors in the brain during age in rats. Proc. Ann. N. Y. Acad. Sci. 673, 206-213.

  17. Bagetta G, Corasanti MT, Aloe L, Berliocchi L, Costa N, Finazzi-Agrò A, Nisticò G (1996) – Intracerebral injection of human immunodeficiency virus type 1 coat protein gp 120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat. Proc. Natl. Acad. Sci. USA, 93, 928-33.

  18. Nisticò R, Piccirilli S, Sebastianelli L, Nisticò G, Bernardi G, Mercuri NB (2007) – The blockade of K(+)-ATP channels has neuroprotective effects of an in vitro model of brain ischemia. Int. Rev. neurobiol. 82, 383-395.

  19. Levi-Montalcini R, Knight RA, Nicotera P, Nisticò G, Bazan N, Melino G (2011) Rita's 102!! Mol. Neurobiol. 2011 Apr;43(2):77-9.

  20. Bornstein S, Ehrhart-Bornstein M, Androutsellis-Theotokis A,, Eisenhofer G, Licinio J, Wong ML, Calissano P, Nisticò G, Levi-Montalcini R (2012) Chromaffin Cells - The Peripheral Brain, Molecular Psychiatry 2012, in press


Selected Volume

  1. Muller EE, Nisticò G & Scapagnini U (1997) Neurotrasmitters and Anterior Pituitary Function. Academic Press. New York. pp. 1-435.

  2. Nisticò G & Bolis L (Eds.) (1983) Progress in Nonmammalian Brain Research. CRC Press. Boca Raton, Florida. Vol. I pp. 1-185.

  3. Nisticò G & Bolis L (Eds.) (1983) Progress in Nonmammalian Brain Research. CRC Press. Boca Raton, Florida. Vol. II pp. 1-224.

  4. Nisticò G & Bolis L (Eds.) (1983) Progress in Nonmammalian Brain Research. CRC Press. Boca Raton, Florida. Vol. III pp. 1-245.

  5. Nisticò G, Di Pierri R & Meinardi H (Eds.) (1983) Epilepsy, an update on research and therapy. Alan Liss Inc. New York. pp. 1-381.

  6. Nisticò G, Morselli PL, Lloyd KG, Fariello RG & Engel J (Eds.) (1985) Neurotrasmitters, seizures and Epilepsy III. Raven Press. New York. pp. 1-505.

  7. Muller EE & Nisticò G (Eds.) (1989) Brain messengers and the Pituitary, Acdemic Press. New York. pp. 1-711.

  8. Vane J, Higgs A, Marsico SA & Nisticò G (Eds. ) (1989) Asthma. Basic mechanism and therapeutic perspectives. Pythagora Press. Roma-Milano. Pp. 1-252.

  9. Placidi GF, Dell’Osso L, Nisticò G & Akiskal HS (Eds.) (1993) Recurrent Mood Disorders. Springer-Verlag, berlin. Pp.1-304.

  10. Moncada S, Nisticò G & Higgs AE (Eds.) (1993) Nitric oxide: Brain and Immune System. Portland Press. London. Pp. 1-293.

  11. Moncada S, Nisticò G, Bagetta G, Higgs AE (Eds.) (1998) Nitric oxide and the Cell, Portland Press, London pp. 1-305.

  12. Nistico G, McGiff J, Born G (Eds.) (2008) In Memory of Sir John Vane, Exòrma, Roma.

  13. Negri L, Melchiorri P, Hökfelt T, Nisticò G (2009) In Memory of Vittorio Erspamer, Exòrma, Roma.

  14. Pepeu GC, Mugelli A, Moroni F, NISTICO’ G (2011) In Memory of Alberto Giotti, Exòrma, Roma.